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Technical studies on high-speed turnouts for china railways
He Huawu
Strategic Study of CAE 2009, Volume 11, Issue 5, Pages 23-30
Keywords: high-speed railway high-speed turnout technical studies
Genome-wide association studies: inherent limitations and future challenges
Yan Du, Jiaxin Xie, Wenjun Chang, Yifang Han, Guangwen Cao
Frontiers of Medicine 2012, Volume 6, Issue 4, Pages 444-450 doi: 10.1007/s11684-012-0225-3
Genome-wide association studies (GWAS) have achieved great success in identifying genetic variantsDeep sequencing followed by functional studies will be needed to elucidate the underpinning biological
Keywords: genome-wide association studies (GWAS) genetic variant cancer limitation challenge
Genomic and pharmacogenetic studies of childhood acute lymphoblastic leukemia
Ching-Hon Pui
Frontiers of Medicine 2015, Volume 9, Issue 1, Pages 1-9 doi: 10.1007/s11684-015-0381-3
With the cure rate of childhood acute lymphoblastic leukemia (ALL) approaching 90%, further improvement in the treatment outcome and quality of life of patients will require better understanding of the mechanisms of drug resistance, identifying new leukemic cell genetic lesions that are amendable to available target therapy, and optimizing treatment based on host pharmacodynamics and pharmacogenomics. Deeper characterization of leukemic cell genetic abnormalities has discovered new subtypes of leukemia such as early T-cell precursor ALL and Philadelphia chromosome-like ALL, and identified many genomic alterations that have diagnostic, prognostic, or therapeutic implications. In this regard, several novel fusion transcripts are responsive to ABL tyrosine kinase inhibitors and potentially to JAK inhibitors. Genome-wide analyses have also unraveled the role of inherited cancer predisposing genes and small nucleotide polymorphisms of several genes in the development of childhood ALL. These advances promise to lead to more sophisticated personalized treatment strategies in the near future.
Keywords: pharmacogenomics acute lymphoblastic leukemia genomics pharmacogenetics
Pathway to energy technical innovation and commercialization based on Internet plus DES
Huiping LIU
Frontiers in Energy 2016, Volume 10, Issue 1, Pages 65-78 doi: 10.1007/s11708-015-0391-5
Keywords: “Internet Plus” distributed energy system (DES) business model technical innovation commercialization
Family planning technical services in China
Shang-Chun WU
Frontiers of Medicine 2010, Volume 4, Issue 3, Pages 285-289 doi: 10.1007/s11684-010-0097-3
Keywords: family planning contraceptive method service delivery
Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 8, doi: 10.1007/s11783-023-1694-0
● Data quality assessment criteria for MP/NPs in food products were developed.
Keywords: Microplastic Nanoplastic Food products Data quality Human health risk
ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT
Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1, doi: 10.15302/J-FASE- 2021390
Creating technical heritage object replicas in a virtual environment
Olga EGOROVA,Dmitry SHCHERBININ
Frontiers of Mechanical Engineering 2016, Volume 11, Issue 1, Pages 108-115 doi: 10.1007/s11465-016-0363-4
The paper presents innovative informatics methods for creating virtual technical heritage replicas3D modeling and animation of aircrafts, spaceships, architectural-engineering buildings, and other technical
Keywords: 3D document history of science and technology technical knowledge popularization virtual environment
Jianxian ZENG, Junfeng LIU, Niandong HUANG,
Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 3, Pages 360-366 doi: 10.1007/s11705-009-0269-3
On Social-technical Control of Safety Development in Economic Transition Background
Xue-qiu He,Song Li
Frontiers of Engineering Management 2015, Volume 2, Issue 3, Pages 234-240 doi: 10.15302/J-FEM-2015025
Keywords: safety development economic growth economic transition social-technical control
Parameter studies on impact in a lap joint
Amir M. RAHMANI,Elizabeth K. ERVIN
Frontiers of Mechanical Engineering 2015, Volume 10, Issue 1, Pages 64-77 doi: 10.1007/s11465-014-0322-x
To represent a loose lap joint, a beam impacting four springs with gaps is modeled. Modal analysis with base excitation is solved, and time histories of contact points are closely monitored. Using the impulse during steady state response, six influential parameters are studied: damping ratio, contact stiffness, intermediate contact position, gap, excitation amplitude and beam height. For all parameters, the system response is highly controlled by modes with two contacting springs. Each parameter’s effect on system response is presented including unstable regions, unique trend behaviours result. Recommendations for structural designers are also noted.
Keywords: impact mechanics contact joint behaviour modal analysis parameter study
Simulation studies on metastable phase equilibria in the aqueous ternary systems (NaCl-MgCl
Tianlong DENG, Baojun ZHANG, Dongchan LI, Yafei GUO
Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 2, Pages 172-175 doi: 10.1007/s11705-009-0048-1
Keywords: green chemistry solar pond technique simulation metastable phase equilibrium solubility
Frontiers of Agricultural Science and Engineering 2023, Volume 10, Issue 1, Pages 31-47 doi: 10.15302/J-FASE-2023482
● Farmer adoption of organic fertilizer and biopesticides was found to be positively correlated.
Keywords: biopesticides green production organic fertilizer technical environment
Experimental studies on the influence of porosity on membrane absorption process
GAO Jian, REN Zhongqi, ZHANG Zeting, ZHANG Weidong
Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 4, Pages 385-389 doi: 10.1007/s11705-007-0070-0
Keywords: de-ionized · L different membrane porosity CO
Influences of Technical Innovation Mode on Innovation Strategy of Energy Enterprises
Lu Zhang,Dan-dan Wang,Min Wang,Ning Hui
Frontiers of Engineering Management 2016, Volume 3, Issue 3, Pages 283-289 doi: 10.15302/J-FEM-2016048
Keywords: energy enterprise technical innovation innovation strategy
Title Author Date Type Operation
Genome-wide association studies: inherent limitations and future challenges
Yan Du, Jiaxin Xie, Wenjun Chang, Yifang Han, Guangwen Cao
Journal Article
Genomic and pharmacogenetic studies of childhood acute lymphoblastic leukemia
Ching-Hon Pui
Journal Article
Pathway to energy technical innovation and commercialization based on Internet plus DES
Huiping LIU
Journal Article
Data quality assessment for studies investigating microplastics and nanoplastics in food products: Are
Journal Article
ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT
Journal Article
Creating technical heritage object replicas in a virtual environment
Olga EGOROVA,Dmitry SHCHERBININ
Journal Article
Experimental studies on extraction of cobalt ions from dilute aqueous solutions by using complexation-ultrafiltration
Jianxian ZENG, Junfeng LIU, Niandong HUANG,
Journal Article
On Social-technical Control of Safety Development in Economic Transition Background
Xue-qiu He,Song Li
Journal Article
Simulation studies on metastable phase equilibria in the aqueous ternary systems (NaCl-MgCl
Tianlong DENG, Baojun ZHANG, Dongchan LI, Yafei GUO
Journal Article
IMPACTS OF TECHNICAL ENVIRONMENT ON THE ADOPTION OF ORGANIC FERTILIZERS AND BIOPESTICIDES AMONG FARMERS
Journal Article
Experimental studies on the influence of porosity on membrane absorption process
GAO Jian, REN Zhongqi, ZHANG Zeting, ZHANG Weidong
Journal Article